• Mariana Oliveira Mourão
  • Elaine de Oliveira Zanini Centro Universitário Assis Gurgacz
Palavras-chave: GABA, Progesterona, Transtorno disfórico pré-menstrual


O transtorno disfórico pré-menstrual (TDPM) é um transtorno psiquiátrico que envolve os hormônios ovarianos que acomete o ciclo GABAérgico do sistema nervoso central da mulher. A partir de um estudo qualitativo, foi levantada uma pesquisa sobre o funcionamento fisiopatológico da doença. Os principais aspectos desenvolvidos foram a ação bimodal da alopregnanolona, a hipótese de tolerância dos receptores GABAA e o uso de progesterona como tratamento da doença. Os resultados da pesquisa indicam que a suplementação de progesterona contribui de maneira agravante à doença, aumentando os sintomas negativos e sendo contraindicada para o tratamento do TDPM.


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